Highly inert Cu(ii) complexes of C-aryl bifunctional cyclam-picolinates with remarkable 64Cu-labelling and biodistribution
Pineau, Julie; Lima, Luis M. P.; Le Roy, Marie M.; Marionneau-Lambot, Severine; Cordier, Marie; Le Saec, Patricia; Zeevaart, Jan Rijn; Driver, Cathryn H. S.; Faivre-Chauvet, Alain; Le Bris, Nathalie; et al
Chem. Commun., 2023, 59, 888-891, DOI: 10.1039/D2CC06602E

Cyclam-picolinate chelators were functionalized via click chem. with an addnl. carboxyl group for subsequent bioconjugation to antibodies or for the modification of the overall charge of the corresponding 64Cu-radiocomplexes. The C-aryl functionalization strategy developed here preserves the chem. properties of the radiocomplexes while deeply enhancing their applications within nuclear medicine.